What is the Origin of Intrinsic Repair?

'Intrinsic' means belonging naturally or essential, and 'repair' comes from the Latin reparare, meaning to restore or mend. This concept is foundational to cellular biology and the study of aging, emphasizing the constant, internal regenerative processes that maintain organismal integrity. The term contrasts with external interventions, highlighting the body's innate regenerative power.

What is the Mechanism of Intrinsic Repair?

The mechanism of intrinsic repair is highly complex and coordinated, initiated by various cellular stress sensors that activate specific signaling pathways. DNA damage, for instance, triggers the poly-ADP-ribose polymerase (PARP) system and other repair enzymes to correct genetic errors. At the cellular level, the process of autophagy is activated to selectively degrade and recycle damaged organelles, particularly mitochondria. Hormonal signals, such as growth hormone and insulin-like growth factor 1 (IGF-1), also play a significant role by promoting cell proliferation and tissue regeneration.

Intrinsic Repair

Meaning

The inherent, genetically programmed capacity of the body’s cells and tissues to detect, mitigate, and reverse damage resulting from metabolic stress, environmental toxins, or physical wear and tear. This fundamental biological process encompasses mechanisms like DNA repair, protein turnover, and the elimination of senescent cells via pathways such as autophagy and apoptosis. Optimal intrinsic repair is a key determinant of biological age, tissue function, and overall longevity. It represents the core of the body’s self-maintenance system.