What is the Origin of Intrinsic Aging?

The term combines "intrinsic," meaning belonging naturally or essential, with "aging," the process of senescence. This concept is a core tenet of gerontology, providing a necessary differentiation from environmentally induced damage. It posits that there is a hard-wired, biological clock dictating a maximum lifespan and rate of decline.

What is the Mechanism of Intrinsic Aging?

The underlying mechanism is rooted in cellular and molecular biology, including mitochondrial dysfunction leading to reduced energy output and increased oxidative stress. Another key driver is the accumulation of senescent cells, which secrete pro-inflammatory cytokines, contributing to "inflammaging." Hormonal changes, such as the age-related decline in DHEA and growth hormone, are considered integral components of this intrinsic, systemic decline.

Intrinsic Aging ∞ Area

Intrinsic Aging

Meaning

Intrinsic aging, also known as chronological aging, refers to the inevitable, genetically programmed, and time-dependent degenerative changes that occur in all organs and tissues, independent of external environmental factors. This internal process is driven by fundamental biological mechanisms such as telomere shortening, cumulative DNA damage, and the progressive decline in cellular replication capacity. It manifests in the skin as fine wrinkles, dryness, and atrophy in sun-protected areas. Intrinsic aging sets the baseline rate of decline, which is then often accelerated by extrinsic factors.