Question 1

What is the Meaning of Intrinsa?

Accepted Answer

Intrinsa was a specific transdermal patch designed to deliver testosterone to women who had undergone surgical menopause and were experiencing hypoactive sexual desire disorder (HSDD). This formulation aimed to restore physiological testosterone levels, which can be significantly diminished after the removal of the ovaries, thereby addressing the associated loss of libido and sexual distress. It represented a targeted, low-dose hormonal replacement approach for a specific female sexual health indication.

Question 2

What is the Origin of Intrinsa?

Accepted Answer

The product name Intrinsa originated from pharmaceutical research efforts in the early 2000s that sought to develop an FDA-approved hormonal treatment for female sexual dysfunction. Its development was based on the clinical evidence linking low androgen levels to diminished sexual desire in postmenopausal women. Although it gained regulatory approval in some international markets, the patch was not ultimately approved for commercial use in the United States.

Question 3

What is the Mechanism of Intrinsa?

Accepted Answer

The patch mechanism is a passive transdermal delivery system, allowing the synthetic testosterone hormone to slowly diffuse across the skin and into the systemic circulation over a 24-hour period. This delivery route is advantageous as it bypasses the first-pass metabolism in the liver, minimizing potential hepatotoxicity and allowing for a lower total daily dose. The absorbed testosterone then acts on central and peripheral androgen receptors to modulate sexual function.

Intrinsa

Meaning

Origin

Mechanism

What Are the Regulatory Hurdles for Female Testosterone Therapy Approval?

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