What is the Origin of Intranasal Peptide Delivery?

The term is a compound of "Intranasal," indicating the route of administration via the nose, "Peptide," referring to the short chain of amino acids that make up the therapeutic agent, and "Delivery," signifying the transport process. This method evolved from the understanding of the unique anatomical connection between the nasal cavity and the brain via the olfactory and trigeminal nerves.

What is the Mechanism of Intranasal Peptide Delivery?

The primary mechanism involves the peptide diffusing across the highly vascularized nasal epithelial lining to enter the bloodstream directly, offering systemic effects. For CNS-targeted delivery, the mechanism leverages the olfactory and trigeminal nerve pathways, allowing the peptide to bypass the restrictive BBB via extracellular and possibly intracellular transport. This direct nose-to-brain route is highly efficient for neuroactive peptides, such as certain growth hormone-releasing hormones or neuroprotective agents, enabling them to modulate central endocrine and neurological function with high precision.

Intranasal Peptide Delivery

Meaning

Intranasal Peptide Delivery is a specialized pharmaceutical administration route that utilizes the nasal mucosa to transport therapeutic peptide molecules directly into the systemic circulation or, crucially, into the central nervous system (CNS). This non-invasive method is particularly advantageous for delivering peptides that would otherwise be rapidly degraded by the gastrointestinal tract or blocked by the blood-brain barrier (BBB). It offers a rapid onset of action and avoids first-pass hepatic metabolism, maximizing the bioavailability of the delicate peptide structure.

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HRTioOctober 7, 2025

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