What is the Origin of Intranasal Peptide Administration?

This delivery method has its roots in traditional medicine and has been refined by modern pharmacology to enhance the bioavailability of fragile biomolecules like peptides. The principle is based on the anatomical and physiological connection between the nasal passages and the brain via the olfactory and trigeminal nerves, offering a non-circulatory route. It has gained prominence with the development of neuro-active peptides that benefit from direct brain access.

What is the Mechanism of Intranasal Peptide Administration?

The mechanism involves the peptide crossing the mucosal epithelium and entering the systemic circulation or, critically, bypassing the blood-brain barrier via the olfactory bulb and trigeminal nerve pathways. This direct nose-to-brain pathway allows for higher concentrations of the peptide to reach target receptors in the brain with minimal systemic metabolism. The method relies on the peptide's physicochemical properties and the formulation's ability to maximize mucosal permeability.

Intranasal Peptide Administration ∞ Area

Intranasal Peptide Administration

Meaning

Intranasal Peptide Administration is a non-invasive route of drug delivery where therapeutic peptides are introduced into the nasal cavity for systemic absorption or direct transport to the central nervous system. This method capitalizes on the rich vascular supply and the unique anatomical proximity of the nasal mucosa to the brain. It is often preferred for peptides that are poorly absorbed orally or are intended to exert direct neurocognitive effects.