Skip to main content

Intramuscular Testosterone Administration Superiority

Meaning

This term posits that Intramuscular (IM) injection is the clinically preferred method for administering testosterone replacement therapy due to its pharmacokinetic advantages in achieving stable, supraphysiologic-to-high-physiologic serum concentrations. The superiority is defined by the reliable depot effect of oil-based esters, which results in predictable absorption and a consistent, therapeutic hormonal profile over a defined dosing interval. This administration route minimizes the extreme peaks and troughs often associated with less frequent injections or transdermal preparations, thus promoting greater symptomatic relief and better compliance.