What is the Origin of Intracellular Receptors?

The discovery of these internal receptors was a pivotal moment in modern endocrinology, explaining how lipid-soluble hormones could traverse the cell membrane to influence nuclear processes. The term is descriptive, combining 'intra' (inside) and 'cellular' (the cell) with 'receptors' (the binding proteins). This receptor class defines the mechanism of action for all steroid and thyroid hormones.

What is the Mechanism of Intracellular Receptors?

The lipophilic nature of steroid hormones allows them to passively diffuse across the cell membrane and into the cell interior. Once inside, the hormone binds to its specific intracellular receptor, which induces a critical conformational change in the receptor protein. This activated hormone-receptor complex then translocates to the nucleus and binds directly to specific DNA sequences, known as hormone response elements (HREs), initiating or repressing the transcription of target genes and thus altering the cell's protein synthesis profile.

Intracellular Receptors

Meaning

Intracellular receptors are a class of protein receptors situated inside the cell, either freely in the cytoplasm or bound within the nucleus, that specifically bind to lipid-soluble signaling molecules. These receptors are the primary mediators of the biological actions of steroid hormones, thyroid hormones, and Vitamin D. Their activation is the fundamental molecular mechanism by which these lipophilic hormones exert their profound, long-term effects on gene expression and cellular function.

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Intracellular Receptors

Meaning

Origin

Mechanism

Master Your Cellular Architecture

The Secret Language of Cells

What Are the Regulatory Differences between Peptides and Traditional Hormones?

How Do Bio-Identical Hormones Interact with Cellular Receptors?

How Do Hormone Protocols Differ for Men and Women?

What Is the First Step to Check My Testosterone?

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