Skip to main content

Intracardiac Aromatase

Meaning

Intracardiac Aromatase refers to the presence and functional activity of the aromatase enzyme, also known as estrogen synthase, specifically within the tissues of the heart. This enzyme is crucial because it catalyzes the final and rate-limiting step in the biosynthesis of estrogens from their androgen precursors, such as testosterone and androstenedione. The local production of estrogen within the myocardium, independent of gonadal sources, suggests a direct autocrine or paracrine role for this hormone in regulating cardiac function and cardiovascular health. Its expression is a key area of study in sex-based differences in heart disease.