What is the Origin of Intestinal Permeability Pathology?

This term is rooted in gastroenterology and immunology, where the measurement of intestinal permeability has become a diagnostic tool for various chronic diseases. The 'pathology' designation emphasizes that this is a disease state, not merely a transient functional change. It is intrinsically linked to the function of tight junction proteins.

What is the Mechanism of Intestinal Permeability Pathology?

The pathology arises from the dysfunction or degradation of the tight junction complexes between colonocytes, often induced by inflammatory mediators, specific dietary components like gluten, or microbial dysbiosis. The resultant increased paracellular transport leads to the translocation of lipopolysaccharide (LPS), which subsequently activates systemic immune cells. This continuous inflammatory signaling contributes to conditions like insulin resistance and altered thyroid hormone metabolism.

Intestinal Permeability Pathology ∞ Area

Intestinal Permeability Pathology

Meaning

Intestinal Permeability Pathology describes the compromised integrity of the gastrointestinal epithelial barrier, often referred to clinically as “leaky gut,” which permits the unregulated passage of luminal contents, such as bacterial endotoxins and undigested food particles, into the submucosa and systemic circulation. This pathological state triggers chronic immune activation and systemic inflammation, significantly impacting endocrine and metabolic health. It represents a critical failure of the body’s largest barrier.