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Intestinal Permeability Management

Meaning

Intestinal Permeability Management is a targeted clinical strategy focused on precisely regulating and actively restoring the structural and functional integrity of the intestinal epithelial barrier, specifically addressing the tight junctions that control the paracellular transport of substances from the gut lumen into the systemic circulation. Increased permeability, often clinically referred to as “leaky gut,” permits the undesirable systemic translocation of microbial toxins and incompletely digested food particles, thereby triggering chronic immune activation and systemic inflammation. Effective management is critical for mitigating the systemic inflammatory burden and its cascading downstream effects on metabolic and endocrine health.