What is the Origin of Intestinal Permeability Hormones?

The concept is a convergence of gastroenterology, immunology, and endocrinology, recognizing the gut as a major site of hormone action and production. Research identified specific endocrine peptides and sex steroids that modulate the structural components of the intestinal lining. It highlights the direct physiological link between endocrine health and gut barrier function.

What is the Mechanism of Intestinal Permeability Hormones?

Hormones such as zonulin, a peptide that modulates tight junctions, and certain sex hormones, like estrogen and progesterone, directly influence the expression and function of proteins that seal the gut barrier. For example, glucocorticoids can impair barrier function under stress, while thyroid hormones are necessary for normal epithelial turnover. Maintaining optimal levels of these permeability-regulating hormones is essential for preventing systemic inflammation and hormonal disruption.

Intestinal Permeability Hormones ∞ Area

Intestinal Permeability Hormones

Meaning

This term refers to the endocrine factors and signaling molecules that directly regulate the integrity of the intestinal barrier, specifically the tight junctions between epithelial cells. Hormones play a crucial role in maintaining low intestinal permeability, which prevents the systemic entry of toxins and undigested food particles. Dysregulation of these hormones can contribute to the compromised barrier function often described as “leaky gut.”