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Intestinal Barrier Permeability

Meaning

Intestinal barrier permeability, often clinically referred to as “leaky gut,” is the measure of how easily substances can pass through the single-cell layer of the intestinal epithelium and enter the underlying tissues and bloodstream. Optimal permeability allows for the controlled, selective absorption of nutrients and water while strictly preventing the paracellular passage of toxins, undigested food particles, and microorganisms. Dysregulated permeability is a key pathological factor in systemic inflammation, immune dysregulation, and the development of chronic metabolic and hormonal issues.