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Interstitial Fibrosis

Meaning

Interstitial Fibrosis is a pathological condition defined by the excessive, abnormal accumulation and deposition of extracellular matrix components, predominantly collagen, within the interstitial space of an organ, often leading to the replacement of functional parenchymal tissue. This pervasive scarring process results in the progressive stiffening and measurable loss of organ compliance, ultimately and severely impairing the tissue’s capacity to perform its normal, essential physiological functions. In critical endocrine organs, such as the testes or the thyroid gland, this condition can significantly contribute to glandular insufficiency and progressive hormonal deficiency.