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Interorganelle Communication Failure

Meaning

Interorganelle Communication Failure refers to the breakdown in the complex, coordinated signaling and material exchange between a cell’s internal membrane-bound compartments, such as the nucleus, mitochondria, endoplasmic reticulum, and peroxisomes. This failure compromises critical cellular processes like energy production, protein synthesis, and lipid metabolism, which are essential for endocrine cell function. It represents a fundamental pathology at the cellular level contributing to aging and hormonal decline.