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Interorgan Crosstalk

Meaning

The intricate, continuous, and bidirectional communication network involving the exchange of hormones, signaling molecules, metabolites, and neural signals between anatomically distinct organs and tissues throughout the body. This constant molecular dialogue is fundamentally essential for maintaining systemic energy balance, homeostatic regulation, and coordinated physiological adaptation to external and internal stimuli. In the context of hormonal health, this crosstalk includes the critical interplay between the brain, skeletal muscle, adipose tissue, and the liver. Disruption of this communication network is often a central feature in the pathology of metabolic and endocrine disorders.