What is the Origin of Intermittent TRT?

This term is an adaptation of continuous hormonal therapy, emerging from clinical practice as an attempt to address concerns about the profound suppression of the Hypothalamic-Pituitary-Gonadal (HPG) axis caused by continuous exogenous testosterone. The concept borrows from the cycling protocols seen in other pharmacological fields, applying a periodic rest to the endocrine system.

What is the Mechanism of Intermittent TRT?

The mechanism of intermittent therapy is based on the hope that the planned breaks from exogenous testosterone will allow the suppressed HPG axis a chance for partial or complete recovery of endogenous luteinizing hormone (LH) and follicle-stimulating hormone (FSH) production. While the testosterone is administered, it provides the therapeutic effect; during the off-cycle, the goal is to prevent permanent testicular atrophy and preserve fertility potential, though evidence for consistent success remains limited.

Intermittent TRT ∞ Area

Intermittent TRT

Meaning

Intermittent TRT refers to a specific therapeutic approach for Testosterone Replacement Therapy (TRT) that involves planned cycles of exogenous testosterone administration followed by scheduled periods of treatment cessation. This strategy contrasts with the standard continuous administration protocol for managing clinical hypogonadism. The clinical rationale for this approach is often debated, but it is sometimes explored to potentially mitigate specific long-term side effects.