What is the Origin of Intermittent Fasting Protocol?

The concept is an application of evolutionary biology and chrononutrition, recognizing that human metabolism is adapted to periods of nutrient scarcity. Modern scientific interest was spurred by animal studies demonstrating longevity and healthspan benefits from calorie restriction, leading to the development of time-based feeding schedules for human application. It has become a cornerstone strategy in metabolic health and wellness.

What is the Mechanism of Intermittent Fasting Protocol?

The core mechanism involves a Systemic Fuel Shift from glucose-based metabolism to fat-based metabolism, which is triggered by the prolonged absence of food intake. Reduced insulin signaling during the fasting phase decreases glucose uptake and promotes the breakdown of stored triglycerides (lipolysis), leading to the production of ketones. This metabolic switch activates stress response pathways, such as sirtuins and AMPK, which enhance cellular resilience and repair.

Intermittent Fasting Protocol

Meaning

A dietary strategy that cycles between periods of voluntary fasting and non-fasting, rather than focusing on what to eat, it emphasizes when to eat. These protocols range from daily time-restricted feeding (e.g., 16/8) to periodic longer fasts (e.g., 24 hours, once or twice a week). Clinically, this approach is used to modulate metabolic flexibility, improve insulin sensitivity, and promote cellular repair mechanisms like autophagy.