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Interleukin-22

Meaning

Interleukin-22 (IL-22) is a specific pleiotropic cytokine belonging to the IL-10 family of signaling molecules, primarily produced by various T helper cell subsets and innate lymphoid cells. This immunoregulatory protein plays a critical role in mucosal immunity, promoting tissue repair, barrier integrity, and antimicrobial defense, particularly in the gastrointestinal tract, skin, and respiratory system. Its function represents a crucial intersection between the immune system and epithelial health, with implications for chronic inflammatory and autoimmune conditions.