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Intercellular Communication Networks

Meaning

Intercellular communication networks represent the complex system of signaling pathways and molecules that govern the interaction and coordination between individual cells within a tissue and across different organ systems. These networks utilize diverse chemical messengers, including hormones, neurotransmitters, cytokines, and growth factors, to regulate essential physiological processes like growth, metabolism, and immune response. Disruption of these networks, often through chronic inflammation or the accumulation of Senescence-Associated Secretory Phenotype (SASP) factors, is a central driver of age-related dysfunction. Maintaining the fidelity of these signaling channels is essential for systemic health and tissue integrity.