Intercellular Communication Fidelity refers to the accuracy, clarity, and reliability with which one cell transmits a signal to an adjacent or distant target cell, ensuring the intended downstream biological response is executed precisely as programmed. In the hormonal context, this describes how effectively a circulating hormone, once bound to its receptor, initiates the correct intracellular cascade without significant signal degradation or crosstalk interference. High fidelity is synonymous with robust physiological regulation.
Origin
This concept is rooted in information theory applied to biology, where ‘fidelity’ implies minimal error in the transmission and reception of molecular messages across biological membranes and signaling networks. It emphasizes that the quality of cellular response depends not just on the signal’s presence but on the integrity of the entire communication chain, from synthesis to final transcriptional output. The term highlights the fragility of complex biological coordination.
Mechanism
Fidelity is maintained through the precise stoichiometry of receptor-ligand binding, the speed and accuracy of second messenger systems, and the appropriate scaffolding of signaling complexes within the cytoplasm. For example, maintaining the correct ratio between estrogen receptor subtypes ensures appropriate gene transcription rather than aberrant signaling. Low fidelity often manifests as reduced target tissue responsiveness, even when systemic hormone levels appear adequate, pointing toward receptor or downstream pathway impairment.
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