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Insuling Sensitivity Score

Meaning

The Insulin Sensitivity Score is a quantitative index, often calculated using fasting glucose and insulin levels (e.g., HOMA-IR), that estimates the efficiency with which peripheral tissues, such as muscle and adipose, respond to circulating insulin. A high score indicates robust cellular responsiveness to insulin signaling, signifying effective glucose disposal mechanisms. Conversely, a low score points toward peripheral insulin resistance, a state strongly linked to metabolic dysfunction and often preceding Type 2 Diabetes. This score is a critical diagnostic marker in metabolic endocrinology. Understanding this metric guides dietary and pharmacological strategies.