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Insulin Signaling Pathways

Meaning

Insulin Signaling Pathways encompass the elaborate network of intracellular molecular reactions that are rapidly triggered following the binding of the peptide hormone insulin to its cognate receptor located on the external surface of target cells, notably adipocytes, hepatocytes, and skeletal muscle cells. The unimpaired functionality of these pathways is absolutely vital for maintaining systemic glucose homeostasis, regulating energy substrate storage, and coordinating cellular growth processes. Conversely, disruption in this cascade is the fundamental biological antecedent to clinical insulin resistance and the development of metabolic syndrome.