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Insulin Signaling Pathway

Meaning

The Insulin Signaling Pathway is a complex cascade of molecular events initiated by the binding of insulin to its specific tyrosine kinase receptor on the cell surface. This pathway is paramount for regulating glucose uptake, lipid metabolism, and protein synthesis in insulin-sensitive tissues like muscle, liver, and fat. Impairment of this pathway, known as insulin resistance, is the central pathological feature of Type 2 diabetes and a significant component of metabolic syndrome.