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Insulin Signaling Efficiency

Meaning

Insulin Signaling Efficiency quantifies the degree to which critical target cells, predominantly in muscle, adipose tissue, and the liver, exhibit a robust and effective response to the binding of the hormone insulin, resulting in necessary glucose uptake and appropriate metabolic action. High efficiency indicates that a minimal concentration of insulin is sufficient to elicit a powerful cellular response, thereby maintaining stable blood glucose levels and facilitating optimal energy storage. A reduction in this efficiency, known clinically as insulin resistance, is a core pathological driver of systemic metabolic dysfunction and widespread hormonal imbalance.