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Insulin Signaling Cascade

Meaning

The Insulin Signaling Cascade is the critical sequence of molecular events initiated when the hormone insulin binds to its specific receptor on the surface of target cells, such as muscle, fat, and liver cells. This cascade is the fundamental mechanism responsible for regulating glucose uptake from the bloodstream and maintaining overall energy homeostasis. A breakdown or impairment in this signaling pathway, known as insulin resistance, is the primary pathological driver for the development of prediabetes, type 2 diabetes, and metabolic syndrome.