The therapeutic process of enhancing the responsiveness of peripheral tissues, particularly skeletal muscle and adipose cells, to endogenous or exogenous insulin signals. Restoration signifies reversing states of insulin resistance, a key driver in metabolic syndrome and type 2 diabetes pathology. Improving sensitivity allows for better glucose homeostasis with lower circulating insulin levels.
Origin
This concept emerged from clinical research identifying insulin resistance as a primary defect preceding overt hyperglycemia. Restoration emphasizes that this responsiveness is often recoverable through physiological adjustments.
Mechanism
Restoration primarily functions by improving the efficiency of the insulin receptor substrate (IRS) signaling cascade within the target cell membrane. This is often achieved by reducing intracellular lipid metabolites that interfere with receptor signaling, a process supported by targeted exercise and specific nutritional strategies. Furthermore, optimizing adipokine profiles contributes to a less inflammatory cellular environment, allowing insulin signaling to proceed unimpeded.
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