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Insulin Sensitivity Linkage

Meaning

Insulin Sensitivity Linkage describes the profound, bidirectional relationship between the body’s cellular responsiveness to insulin and the optimal function of the entire endocrine system, particularly the sex and adrenal hormone axes. High insulin sensitivity is characterized by efficient glucose uptake by cells, which is metabolically favorable and promotes hormonal balance. Conversely, insulin resistance, or poor sensitivity, is a core driver of systemic inflammation and is strongly linked to polycystic ovary syndrome (PCOS), visceral fat accumulation, and suppression of Sex Hormone-Binding Globulin (SHBG) production. Clinically, optimizing insulin sensitivity is a foundational step for correcting many complex hormonal dysregulations.