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Insulin Sensitivity Divergence

Meaning

Insulin Sensitivity Divergence refers to the clinical observation that individuals in a close dyadic relationship, despite often sharing similar genetic backgrounds, dietary habits, and lifestyle exposures, can exhibit markedly different degrees of cellular responsiveness to insulin. One partner may maintain excellent glucose homeostasis, while the other develops significant insulin resistance. This divergence highlights the crucial role of individualized metabolic and hormonal factors in health outcomes. It challenges the assumption of shared metabolic risk in a shared environment.