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Insulin Sensitivity Decline

Meaning

Insulin Sensitivity Decline is a physiological state characterized by a reduced responsiveness of target tissues, primarily muscle, fat, and liver cells, to the signaling action of the hormone insulin. This diminished sensitivity requires the pancreas to secrete increasingly larger amounts of insulin to maintain normal blood glucose levels, leading to a state of hyperinsulinemia. The decline in sensitivity is a critical precursor to metabolic syndrome, type 2 diabetes, and various other chronic diseases, reflecting a fundamental disruption in glucose and energy homeostasis. Clinical assessment aims to detect this decline early to implement restorative metabolic interventions.