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Insulin Sensitivity Brain Fuel

Meaning

Insulin Sensitivity Brain Fuel refers to the critical physiological relationship where the brain’s ability to efficiently utilize glucose as its primary fuel source is directly dependent on the sensitivity of its cells to the hormone insulin. While the brain was once considered largely insulin-independent for glucose uptake, research confirms that insulin signaling is vital for regulating neuronal glucose metabolism, synaptic function, and overall energy homeostasis within the central nervous system. Optimal insulin sensitivity ensures a stable, efficient fuel supply, whereas resistance contributes to metabolic stress and cognitive impairment.