What is the Origin of Insulin Resistance Progression?

The concept is foundational to modern endocrinology and metabolism, describing the cellular inability to properly utilize glucose due to impaired insulin signaling. 'Progression' emphasizes the time-dependent worsening of this metabolic dysfunction if left unaddressed.

What is the Mechanism of Insulin Resistance Progression?

The progression is initiated by chronic overnutrition and physical inactivity, leading to excessive lipid accumulation in non-adipose tissues and chronic low-grade inflammation. These factors interfere with the intracellular signaling pathways of the insulin receptor, impairing the translocation of GLUT4 transporters to the cell membrane and reducing glucose uptake, thereby requiring the pancreas to secrete increasingly larger amounts of insulin.

Insulin Resistance Progression

Meaning

Insulin Resistance Progression is the gradual decline in the responsiveness of peripheral tissues, such as muscle, fat, and liver cells, to the action of the hormone insulin, leading to compensatory hyperinsulinemia and eventually hyperglycemia. This pathological trajectory is a central feature in the development of metabolic syndrome and type 2 diabetes. Clinical focus is placed on arresting or reversing this progression early.