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Insulin Resistance Pathogenesis

Meaning

Insulin Resistance Pathogenesis refers to the complex biological and molecular processes that lead to the diminished ability of cells, particularly those in muscle, fat, and liver tissue, to respond effectively to the hormone insulin. This state necessitates the pancreas to secrete increasingly higher amounts of insulin to maintain normal blood glucose levels, eventually leading to hyperinsulinemia and metabolic dysfunction. Understanding the pathogenesis is critical, as it is a central precursor to Type 2 Diabetes, cardiovascular disease, and other chronic health conditions. Clinically, identifying the earliest molecular events is key to effective preventative and reversal strategies.