What is the Origin of Insulin Resistance Neuroinflammation?

This compound term links "insulin resistance," the diminished cellular response to insulin, with "neuroinflammation," the activation of the brain's immune cells (microglia). The clinical connection highlights the central role of metabolic health in brain pathology.

What is the Mechanism of Insulin Resistance Neuroinflammation?

When neurons and glial cells become resistant to insulin, their glucose uptake and energy metabolism are compromised, leading to cellular stress. This stress activates microglia, which release pro-inflammatory cytokines, creating a hostile environment for synaptic plasticity and neuronal survival. The inflammatory mediators further exacerbate insulin resistance, creating a self-perpetuating cycle of metabolic and neurological decline.

Insulin Resistance Neuroinflammation

Meaning

Insulin resistance neuroinflammation describes the detrimental interplay where impaired insulin signaling within the central nervous system leads to chronic inflammatory processes in the brain. This condition, often linked to systemic metabolic dysfunction, disrupts neuronal communication, impairs mitochondrial function, and accelerates neurodegenerative changes. It is a critical factor in the metabolic-cognitive decline spectrum.