What is the Origin of Insulin Resistance Neurodegeneration?

This concept bridges endocrinology (insulin resistance) and neurology (neurodegeneration), highlighting the brain's dependence on insulin signaling for metabolic health. The term reflects the growing recognition that metabolic dysregulation is a core driver of certain neurodegenerative conditions.

What is the Mechanism of Insulin Resistance Neurodegeneration?

Impaired insulin signaling in neurons leads to reduced phosphorylation of key substrates necessary for synaptic function and energy production. Consequently, mitochondrial dysfunction increases oxidative stress within the neural environment, triggering inflammatory cascades mediated by glial cells. This chronic inflammatory state, fueled by metabolic stress, ultimately promotes tau hyperphosphorylation and amyloid-beta plaque formation, characteristic hallmarks of neurodegeneration.

Insulin Resistance Neurodegeneration ∞ Area

Insulin Resistance Neurodegeneration

Meaning

Insulin Resistance Neurodegeneration describes the pathological cascade where impaired insulin signaling within the central nervous system contributes to neuronal dysfunction and eventual cell death, sometimes termed Type 3 Diabetes. This state compromises cerebral energy metabolism and synaptic integrity, leading to measurable cognitive deficits. Clinically, this represents a failure of neural tissue to properly utilize glucose despite circulating insulin presence.