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Insulin Resistance Impact

Meaning

Insulin resistance impact describes the wide-ranging physiological and clinical consequences that arise when cells fail to respond effectively to the hormone insulin. This metabolic dysfunction necessitates the pancreas to secrete excessive insulin to maintain normal blood glucose levels, leading to hyperinsulinemia. The impact extends far beyond glucose dysregulation, profoundly affecting the endocrine system, promoting visceral fat accumulation, and increasing the risk for cardiovascular disease and Type 2 diabetes. In hormonal health, insulin resistance can directly alter the balance of sex hormones by increasing androgen production and reducing sex hormone-binding globulin (SHBG).