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Insulin Resistance Hormones

Meaning

Insulin Resistance Hormones encompass the spectrum of endocrine signaling molecules whose altered levels or signaling cascades actively contribute to, or result from, the impaired cellular response to insulin action across target tissues. Key players include excess cortisol, elevated growth hormone, specific sex hormone imbalances, and adipokines secreted by dysfunctional adipose tissue itself. These hormones interfere with the downstream effects of insulin at the cellular membrane and within core metabolic pathways, which is central to managing metabolic syndrome.