Question 1

What is the Meaning of Insulin Resistance Endocrine Effect?

Accepted Answer

Insulin Resistance Endocrine Effect refers to the broad, disruptive influence that diminished cellular sensitivity to insulin has on the entire endocrine system, extending far beyond glucose metabolism. This condition triggers compensatory hyperinsulinemia, which acts as a powerful endocrine signal, directly altering the production, transport, and metabolism of various hormones, including sex steroids, cortisol, and growth hormone. It is a central pathological driver in numerous hormonal health issues.

Question 2

What is the Origin of Insulin Resistance Endocrine Effect?

Accepted Answer

The concept stems from the fundamental understanding of insulin's role as a major anabolic and regulatory hormone, not just a glucose transporter. The term gained clinical importance with the recognition of the strong correlation between insulin resistance, metabolic syndrome, and conditions like Polycystic Ovary Syndrome (PCOS) and male hypogonadism. This perspective positions insulin resistance as a systemic endocrine disruptor.

Question 3

What is the Mechanism of Insulin Resistance Endocrine Effect?

Accepted Answer

The primary mechanism involves hyperinsulinemia directly acting on the liver and the gonads. In the liver, elevated insulin potently suppresses the synthesis of Sex Hormone-Binding Globulin (SHBG), increasing the free fraction of sex hormones. In the ovaries and adrenal glands, insulin acts synergistically with luteinizing hormone (LH) to enhance androgen production. This multifaceted endocrine effect leads to a common clinical presentation of elevated free androgens and an overall state of hormonal dysregulation that perpetuates metabolic dysfunction.

Insulin Resistance Endocrine Effect

Meaning

Origin

Mechanism

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