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Insulin Resistance Cognitive Decline

Meaning

Insulin Resistance Cognitive Decline describes the progressive impairment of executive function, memory, and processing speed that is causally linked to or highly correlated with chronic peripheral and central insulin resistance. In this condition, brain cells, particularly neurons and glia, become less responsive to insulin, which is essential for glucose uptake, synaptic plasticity, and neurotransmitter balance. Clinically, this phenomenon underscores the critical metabolic connection between impaired glucose homeostasis and neurodegeneration, often referred to as Type 3 Diabetes in advanced cases. Managing insulin sensitivity is therefore a critical strategy for neuroprotection and maintaining cognitive longevity.