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Insulin Resistance Brain Function

Meaning

Insulin Resistance Brain Function describes the adverse neurobiological state resulting from reduced sensitivity of neuronal and glial cells to the hormone insulin, particularly within key cognitive and regulatory centers like the hippocampus and hypothalamus. This resistance leads to impaired glucose uptake, compromised neuronal energy metabolism, and disrupted insulin signaling within the brain tissue. Clinically, this condition is strongly associated with cognitive decline, mental fog, and is recognized as a significant contributor to neurodegenerative pathology.