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Insulin Receptor Expression

Meaning

Insulin Receptor Expression refers to the quantity and functional state of the specific cell-surface glycoprotein receptors present on target cells, such as adipocytes, myocytes, and hepatocytes, which bind to the hormone insulin. The level of expression, meaning the number of receptors available, and their structural integrity are critical determinants of tissue sensitivity to insulin and, consequently, of systemic glucose homeostasis. Reduced or impaired receptor expression is a key characteristic of insulin resistance and type 2 diabetes pathology. Hormonal balance and lifestyle factors significantly influence this expression profile.