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Insulin-Growth Hormone Seesaw

Meaning

The Insulin-Growth Hormone Seesaw describes a fundamental reciprocal relationship between insulin and growth hormone, two pivotal endocrine regulators of metabolism and growth. When insulin levels are elevated, typically after nutrient intake, growth hormone secretion and action are generally suppressed. Conversely, during periods of nutrient scarcity or fasting, insulin levels decline, which then permits an increase in growth hormone release and activity, reflecting the body’s adaptive metabolic state.