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Insulin Antagonism Mechanism

Meaning

The Insulin Antagonism Mechanism describes the physiological pathways and molecular processes through which certain hormones or factors counteract the anabolic and glucose-lowering effects of insulin. This antagonism is a key feature of insulin resistance, where target cells, particularly muscle and adipose tissue, become less responsive to insulin signaling. Chronic activation of this mechanism leads to compensatory hyperinsulinemia, contributing significantly to metabolic dysfunction and type 2 diabetes pathogenesis. Identifying the specific antagonistic factors is critical for therapeutic intervention.