What is the Origin of Inositol Dysregulation?

The term arises from endocrinology research, primarily focusing on the molecular pathogenesis of Polycystic Ovary Syndrome, or PCOS, and Type 2 Diabetes. Initial studies observed that women with PCOS often exhibit a defect in the insulin-dependent conversion of myo-inositol to D-chiro-inositol. This finding established inositol's role as a key intracellular mediator, leading to the concept that its faulty metabolism drives core aspects of the syndrome.

What is the Mechanism of Inositol Dysregulation?

Inositol isomers function as second messengers that relay the signal from the activated insulin receptor on the cell surface to the intracellular machinery. Dysregulation, such as a deficiency of D-chiro-inositol, impairs the proper activation of glucose transporter proteins, leading to reduced glucose uptake and systemic hyperinsulinemia. In the ovary, this hyperinsulinemia exacerbates androgen production by ovarian theca cells, thereby disrupting follicular development and promoting the hyperandrogenism characteristic of PCOS.

Inositol Dysregulation ∞ Area

Inositol Dysregulation

Meaning

Inositol Dysregulation describes an abnormality in the metabolism or cellular signaling of inositol isomers, particularly myo-inositol and D-chiro-inositol, which are essential second messengers for the insulin receptor pathway. This condition is characterized by an imbalance in the ratio of these isomers, often resulting in compromised insulin signal transduction. The clinical consequence is a state of cellular insulin resistance that contributes significantly to metabolic and reproductive dysfunction.