Pharmaceutical preparations of hormones, typically steroid hormones like testosterone or estrogen, or peptide hormones like human chorionic gonadotropin (hCG), formulated for subcutaneous or intramuscular administration. This route of delivery is favored in clinical practice because it bypasses first-pass metabolism in the liver, leading to higher bioavailability and more predictable serum concentrations compared to oral forms. Injectable preparations are a cornerstone of many hormone replacement and optimization therapies.
Origin
The use of injections for systemic drug delivery dates back to the mid-19th century, while the injection of purified glandular extracts and, later, synthetic hormones became common in the early 20th century as endocrinology advanced. The term simply describes the route of administration for the active hormonal agent.
Mechanism
The hormone, often dissolved in an oil-based vehicle for steroid hormones or reconstituted in a sterile diluent for peptides, is introduced directly into the muscle or subcutaneous tissue. From the injection site, the hormone is slowly absorbed into the bloodstream, creating a sustained release profile that minimizes fluctuations in serum levels. This pharmacokinetic advantage allows for less frequent dosing and a more stable hormonal environment, which is crucial for therapeutic efficacy and patient comfort.
Ensuring the sterility of your compounded therapy is a global challenge of harmonizing international standards to protect your personal health journey.
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