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Inhibitory-Excitatory Ratio

Meaning

The Inhibitory-Excitatory Ratio (I/E Ratio) is a core concept in neurophysiology that quantifies the dynamic balance between neuronal signals that suppress (inhibit) and those that stimulate (excite) postsynaptic activity. This ratio is a critical determinant of network stability, information processing, and overall brain function, including mood and cognitive performance. Clinically, an imbalance in this ratio, often due to neurotransmitter dysfunction, can contribute to conditions like anxiety, seizures, or impaired focus. Maintaining an optimal I/E ratio is paramount for neurological and mental wellness.