What is the Origin of Inhibin B Marker?

Inhibins are part of the transforming growth factor beta (TGF-β) superfamily of hormones, initially discovered for their capacity to inhibit pituitary function. Inhibin B, specifically, is predominantly produced by the ovarian granulosa cells in females and the Sertoli cells in the male testes.

What is the Mechanism of Inhibin B Marker?

The hormone's primary physiological mechanism is the selective negative feedback suppression of Follicle-Stimulating Hormone (FSH) secretion from the anterior pituitary gland. By inhibiting FSH, Inhibin B plays a crucial role in regulating the follicular phase of the menstrual cycle and modulating spermatogenesis, providing a direct hormonal link in the hypothalamic-pituitary-gonadal axis.

Inhibin B Marker ∞ Area

Inhibin B Marker

Meaning

The Inhibin B Marker is a heterodimeric protein hormone used in clinical practice as a biochemical indicator of gonadal function in both women and men. In the context of female reproductive health, a day three serum level of Inhibin B is a key marker for assessing ovarian reserve and the remaining pool of developing follicles. It is also utilized as a tumor marker for certain ovarian cancers.