What is the Origin of Inflammatory Status?

The term originates from clinical immunology and pathology, recognizing that inflammation is not only an acute response to injury but also a chronic, subclinical condition. The "status" component implies a measurable, persistent state of immune activation. It is a critical diagnostic indicator in the hormonal and metabolic health space, often linked to visceral fat and insulin resistance.

What is the Mechanism of Inflammatory Status?

Chronic inflammation is often driven by dysfunctional adipose tissue, particularly visceral fat, which releases pro-inflammatory adipokines and cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). These signaling molecules interfere with insulin receptor signaling, leading to peripheral insulin resistance. Furthermore, they can disrupt the hypothalamic-pituitary axes, negatively affecting the secretion and function of key regulatory hormones like cortisol and testosterone.

Inflammatory Status

Meaning

Inflammatory Status is a clinical measure of the level of chronic, low-grade systemic inflammation present in the body, typically assessed by quantifying specific circulating biomarkers like high-sensitivity C-reactive protein (hs-CRP) and various cytokines. Elevated inflammatory status is a significant underlying factor in metabolic dysfunction, hormonal imbalance, and the progression of age-related diseases. Managing this status is central to preventative health and optimizing systemic resilience.