Inflammatory Response Downregulation is the active suppression or attenuation of the body’s immune-mediated inflammatory cascade, often mediated by counter-regulatory hormones or specialized signaling molecules.
Origin
This phrase merges ‘Inflammatory Response,’ the body’s defense mechanism, with ‘Downregulation,’ indicating a reduction in the activity or quantity of signaling components.
Mechanism
Key mechanisms involve the actions of glucocorticoids, which inhibit the transcription of pro-inflammatory cytokines, or the induction of anti-inflammatory mediators that actively resolve tissue injury and return the system toward endocrine homeostasis.
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