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Inflammatory Microenvironment

Meaning

The localized cellular and biochemical milieu within a specific tissue or organ that is characterized by the persistent presence of pro-inflammatory cytokines, chemokines, and activated immune cells. This microenvironment is a critical, localized driver of chronic disease and the aging process, as it actively compromises local tissue integrity and impairs normal repair mechanisms. In the context of hormonal health, it often directly impairs endocrine gland function and hormone receptor sensitivity.