What is the Origin of Inflammatory Mediator Mapping?

The term originates from immunology and clinical pathology, applying the concept of molecular profiling to the complex network of inflammatory signaling. Mapping implies a detailed, systemic approach to understanding the inflammatory landscape, moving beyond single markers to a comprehensive pattern analysis. This diagnostic approach is crucial for managing chronic diseases and age-related decline.

What is the Mechanism of Inflammatory Mediator Mapping?

The inflammatory mediators are synthesized by immune cells and adipocytes in response to stress or cellular damage, acting as paracrine and endocrine signals. Chronic, low-grade inflammation directly impairs hormonal health by inducing peripheral insulin resistance and inhibiting the hypothalamic-pituitary axis. The mechanism involves inflammatory cytokines interfering with receptor signaling and increasing the expression of inhibitory proteins.

Inflammatory Mediator Mapping ∞ Area

Inflammatory Mediator Mapping

Meaning

Inflammatory Mediator Mapping is the comprehensive biochemical analysis and quantification of circulating and tissue-specific signaling molecules—cytokines, chemokines, and acute-phase proteins—that orchestrate the inflammatory response. This mapping identifies the specific profile of pro- and anti-inflammatory mediators, such as C-reactive protein (CRP), Interleukins (IL-6, IL-10), and Tumor Necrosis Factor-alpha (TNF-α), to pinpoint the source and severity of chronic systemic inflammation. It is a key diagnostic tool for identifying subclinical inflammation that impairs hormonal function.